RESEARCH INDEX
据徐帆学术履历整理的完整题录：104 条期刊文献（去重后）与 15 条履历所列软件著作权登记条目（仅据履历列示）。
RESEARCH TIMELINE · 2006—2026
25 条研究记录，按现有材料所载发表时间从早到晚排列。三篇研究快读提供完整介绍，其余条目保留事实摘要与可用原文链接；全量 CV 题录继续列于下方。
团队学术动态介绍个人及合作研究经历；论文致谢仅表示已确认主体获专业讨论致谢；科学视觉记录论文采用作品图的关系。各类研究均不据此推定为公司研发、资助或产品能力。
显示全部 25 条研究记录
脊髓损伤细胞移植治疗进展的中文文献，本条按题录收录。
现有证据只支持履历中的英文题录；原始期刊链接未返回对应记录，不补写研究结果。
出处见下方 CV 全量题录；现有材料仅支持题录记录。
Xu F et al (2006) The progress of cell transplantation in spinal cord injury, J Sichuan Physiology,28(3),123-125(Chinese)
题录 P0246 · CV 标注年 2006 · 日期依据 cv_listed_year_only。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
脊髓损伤模型建立与神经功能评价研究的中文文献，本条按题录收录。
动物模型线索不能替代人体临床证据。
出处见下方 CV 全量题录；现有材料仅支持题录记录。
Xu F et al (2007) Establishment of spinal cord injury models and its evaluation of neural function after spinal cord injury ,J Trauma Surgery, 1:91-93 (Chinese)
题录 P0244 · CV 标注年 2007 · 日期依据 cv_listed_year_only。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
研究通过观察建立并验证食蟹猴行为分类，形成用于后续观察的行为谱。属于非人灵长类动物行为方法研究。
不能推断该方法直接演化为公司声音算法。
阅读研究快读 → · 论文 DOI · PubMed 22662158
Construction and validation of a systematic ethogram of Macaca fascicularis in a free enclosure.
题录 P0241 · CV 标注年 2012 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
Behavioral studies in non-human primates have become ideal models for further investigations into advanced cognitive function in humans. To date, there is no systematic ethogram of the cynomolgus monkey (Macaca fascicularis) in a free enclosure. In a field observation of 6012 subjects, 107 distinct behaviors of M. fascicularis were preliminarily described. 83 of these behaviors were then independently validated through a randomized cohort and classified into 12 behavioral categories. 53 of these behaviors were then selected to accurately reflect the daily mundane activity of the species in a free enclosure. These findings systematically document the behavior of M. fascicularis in a free enclosure for use in further investigations.
研究比较社会隔离及叠加视觉隔离对成年雌性食蟹猴行为的影响，观察到不同程度的抑郁样行为变化。
动物抑郁样行为不等于人的抑郁症诊断；作者位次另核。
Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis.
题录 P0239 · CV 标注年 2013 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods--social isolation and social plus visual isolation--which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting.
研究采用盲法行为编码，比较抑郁样与健康雌性食蟹猴在育幼情境下的行为差异。
结论限动物与观察情境，不写成人类情绪传染。
The mutual influences between depressed Macaca fascicularis mothers and their infants.
题录 P0236 · CV 标注年 2014 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Objective To assess the influence of infant rearing on the behavior of depressed adult female Macaca fascicularis and the influence of depressed infant-rearing adult female Macaca fascicularis on their infants in a free enclosure environment. Methods Here, 20 depressed subjects and then 20 healthy subjects were randomly selected from a total population of 1007 adult female Macaca fascicularis subjects. Four depressed subjects and eight healthy subjects were rearing infants. By focal observation, three trained observers video-recorded the selected subjects over a total observational period of 560 hours. The video footage was analyzed by qualified blinded analysts that coded the raw footage into quantitative behavioral data (i.e., durations of 53 pre-defined behavioral items across 12 behavioral categories) for statistical analysis. Results Between infant-rearing and non-rearing healthy subjects, ten differential behaviors distributed across five behavioral categories were identified. Between infant-rearing and non-rearing depressed subjects, nine behaviors distributed across five behavioral categories were identified. Between infant-rearing healthy and infant-rearing depressed subjects, fifteen behaviors distributed across six behavioral categories were identified. Conclusion Infant-rearing depressed adult female Macaca fascicularis subjects may have a worse psychological status as compared to non-rearing depressed counterparts. Infant rearing may negatively influence depressed Macaca fascicularis mothers. Infant-rearing depressed subjects were less adequate at raising infants as compared to infant-rearing healthy subjects. Thus, maternal depression in this macaque species may negatively impact infatile development, which is consistent with previous findings in humans.
研究描述食蟹猴社会群体中的自然发生抑郁样表型及血清代谢差异，并讨论模型效度。
原文氯胺酮检验未证实预测效度，不能写模型已全面验证。
Macaques exhibit a naturally-occurring depression similar to humans.
题录 P0233 · CV 标注年 2015 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors - do not realistically resemble the etiopathological development of depression, which occurs naturally in a social context. A non-human primate model that better reflects the social ethological aspects of depression would be more advantageous to investigating pathophysiological mechanisms and developing antidepressant therapeutics. Here, we describe and model a naturally-occurring depressive state in a non-human primate species, the cynomolgus monkey (Macaca fascicularis), in a realistic social ethological context and associate the depressed behavioral phenotype with significant serum metabolic perturbations. One to two subjects per stable social colony (17-22 subjects) manifested a depressive phenotype that may be attributed to psychosocial stress. In accordance with rodent and human studies, the serum metabolic phenotype of depressed and healthy subjects significantly differed, supporting the model's face validity. However, application of the fast-acting antidepressant ketamine failed to demonstrate predictive validity. This study proposes a non-human primate depression model in a realistic social ethological context that can better approximate the psychosocial stressors underlying depression.
研究分析外周血淋巴细胞转录组，比较重性抑郁与亚临床症状性抑郁的共表达及调控特征。
计算分析与临床分型工具不同，不宣称已形成公司诊断服务。
Differential co-expression and regulation analyses reveal different mechanisms underlying major depressive disorder and subsyndromal symptomatic depression.
题录 P0234 · CV 标注年 2015 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
Background Recent depression research has revealed a growing awareness of how to best classify depression into depressive subtypes. Appropriately subtyping depression can lead to identification of subtypes that are more responsive to current pharmacological treatment and aid in separating out depressed patients in which current antidepressants are not particularly effective. Differential co-expression analysis (DCEA) and differential regulation analysis (DRA) were applied to compare the transcriptomic profiles of peripheral blood lymphocytes from patients with two depressive subtypes: major depressive disorder (MDD) and subsyndromal symptomatic depression (SSD). Results Six differentially regulated genes (DRGs) (FOSL1, SRF, JUN, TFAP4, SOX9, and HLF) and 16 transcription factor-to-target differentially co-expressed gene links or pairs (TF2target DCLs) appear to be the key differential factors in MDD; in contrast, one DRG (PATZ1) and eight TF2target DCLs appear to be the key differential factors in SSD. There was no overlap between the MDD target genes and SSD target genes. Venlafaxine (Efexor™, Effexor™) appears to have a significant effect on the gene expression profile of MDD patients but no significant effect on the gene expression profile of SSD patients. Conclusion DCEA and DRA revealed no apparent similarities between the differential regulatory processes underlying MDD and SSD. This bioinformatic analysis may provide novel insights that can support future antidepressant R&D efforts.
Meta分析纳入13项研究、1148名患者，比较丘脑底核与苍白球内侧部刺激的运动、用药及情绪结局。
不同结局各有权衡；不是个人治疗建议，也不是公司医疗技术。
Deep brain stimulation of pallidal versus subthalamic for patients with Parkinson's disease: a meta-analysis of controlled clinical trials.
题录 P0231 · CV 标注年 2016 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Background Parkinson's disease (PD) is a common neurodegenerative disorder that affects many people every year. Deep brain stimulation (DBS) is an effective nonpharmacological method to treat PD motor symptoms. This meta-analysis was conducted to evaluate the efficacy of subthalamic nucleus (STN)-DBS versus globus pallidus internus (GPi)-DBS in treating advanced PD. Methods Controlled clinical trials that compared STN-DBS to GPi-DBS for short-term treatment of PD in adults were researched up to November 2015. The primary outcomes were the Unified Parkinson's Disease Rating Scale Section (UPDRS) III score and the levodopa-equivalent dosage (LED) after DBS. The secondary outcomes were the UPDRS II score and the Beck Depression Inventory (BDI) score. Results Totally, 13 studies containing 1,148 PD patients were included in this meta-analysis to compare STN-DBS versus GPi-DBS. During the off-medication state, the pooled weighted mean difference (WMD) of UPDRS III and II scores were -2.18 (95% CI =-5.11 to 0.74) and -1.96 (95% CI =-3.84 to -0.08), respectively. During the on-medication state, the pooled WMD of UPDRS III and II scores were 0.15 (95% CI =-1.14 to 1.44) and 1.01 (95% CI =0.12 to 1.89), respectively. After DBS, the pooled WMD of LED and BDI were -254.48 (95% CI =-341.66) and 2.29 (95% CI =0.83 to 3.75), respectively. Conclusion These results indicate that during the off-medication state, the STN-DBS might be superior to GPi-DBS in improving the motor function and activities of daily living for PD patients; but during the on-medication state, the opposite result is observed. Meanwhile, the STN-DBS is superior at reducing the LED, whereas the GPi-DBS shows a significantly greater reduction in BDI score after DBS.
文章从抗抑郁药物、基因表达、系统生物学、代谢与脑环路研究讨论抑郁障碍机制，并回顾相关研究进展。
根据原出版商全文概述；不将文献讨论改写为作者新完成的实验或产品效果。
Approaching to the Essence of Major Depressive Disorder
题录 P0229 · CV 标注年 2018 · 日期依据 crossref_published_and_publisher_fulltext。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
网络Meta分析纳入23项随机对照试验，比较19种方案的生存与治疗相关毒性，强调获益与风险的平衡。
排序概率不等于对个体患者的最佳治疗；CV卷年与在线日期不同。
Meta‑analysis of current chemotherapy regimens in advanced pancreatic cancer to prolong survival and reduce treatment‑associated toxicities.
题录 P0227 · CV 标注年 2019 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Unresectable advanced pancreatic cancer (APC) is a highly lethal malignancy. Although numerous chemotherapeutic regimens are available, evidence regarding the survival extension, the life quality improvement, the associated risks and occurrence rates of adverse effects, is required. The effects of 19 chemotherapy regimens on survival and treatment‑associated toxicities in the context of APC treatment were comparatively assessed. A total of 23 randomized controlled trials were included in this network meta‑analysis. For overall survival, five regimens, Gemcitabine (Gem)+radiotherapy (Radio), Gem+cisplatin (Cis), Gem+erlotinib (Erl)+bevacizumab (Bev), Gem+capecitabine (Cap)+Erl, and Gem+exatecan, were the most effective treatments, according to their respective high surface under the cumulative ranking (SUCRA) probabilities. Regarding the progression‑free survival, five regimens, including Gem+Radio, Gem+Erl+Bev, Gem+Cis, Gem+Cap+Erl and Gem+pemetrexed, were the most effective treatments based on their SUCRA probabilities. Each regimen exhibited advantages and disadvantages, and 14 common treatment‑associated toxicities were present in different proportions. The three principal toxic effects included haematological, gastrointestinal and constitutional symptoms. To improve survival, chemotherapy regimens with high SUCRA probabilities require prioritizing. Although treatment‑associated toxicities are unavoidable, the regimens presented toxicities in distinct proportions. Therefore, clinicians should assess the disease status of the patients, and balance the benefits and risks of the selected treatment.
文章回顾帕金森病患者嗓音、构音及声带运动的变化，讨论运动控制与发声机制的研究线索。
据原出版商全文概述；文中讨论早期识别潜力，不等于已验证的筛查产品。
Vocal changed in Parkinson’s disease patients
题录 P0225 · CV 标注年 2019 · 日期依据 cv_listed_year_only。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
研究比较35名帕金森病患者与26名健康对照的发音测试，分析基频、微扰、时长和强度等声学差异。
样本内差异不是音豆纪诊断效能；共同一作及署名含义发布前核原文。
阅读研究快读 → · 论文 DOI · PubMed 32678256
The physical significance of acoustic parameters and its clinical significance of dysarthria in Parkinson's disease.
题录 P0217 · CV 标注年 2020 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
Dysarthria is universal in Parkinson's disease (PD) during disease progression; however, the quality of vocalization changes is often ignored. Furthermore, the role of changes in the acoustic parameters of phonation in PD patients remains unclear. We recruited 35 PD patients and 26 healthy controls to perform single, double, and multiple syllable tests. A logistic regression was performed to differentiate between protective and risk factors among the acoustic parameters. The results indicated that the mean f0, max f0, min f0, jitter, duration of speech and median intensity of speaking for the PD patients were significantly different from those of the healthy controls. These results reveal some promising indicators of dysarthric symptoms consisting of acoustic parameters, and they strengthen our understanding about the significance of changes in phonation by PD patients, which may accelerate the discovery of novel PD biomarkers.
CV和Crossref题录确认一篇基于PowerShell的健康数据分析框架论文。本轮没有正文，不写性能或部署案例。
在线2020年与卷期2021年需并列；不能改写为公司工程交付。
PowerShell-based novel framework for Big health data analysis
题录 P0214 · CV 标注年 2020 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
研究围绕粪便显微图像中的优势细胞定位与识别开展算法实验，采用Faster R-CNN及ResNet相关方法。
必须保留样本类型；论文模型结果不等于当前产品或临床上线。
Fast and accurate automated recognition of the dominant cells from fecal images based on Faster R-CNN.
题录 P0211 · CV 标注年 2021 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
Fecal samples can easily be collected and are representative of a person's current health state; therefore, the demand for routine fecal examination has increased sharply. However, manual operation may pollute the samples, and low efficiency limits the general examination speed; therefore, automatic analysis is needed. Nevertheless, recognition exhaustion time and accuracy remain major challenges in automatic testing. Here, we introduce a fast and efficient cell-detection algorithm based on the Faster-R-CNN technique: the Resnet-152 convolutional neural network architecture. Additionally, a region proposal network and a network combined with principal component analysis are proposed for cell location and recognition in microscopic images. Our algorithm achieved a mean average precision of 84% and a 723 ms detection time per sample for 40,560 fecal images. Thus, this approach may provide a solid theoretical basis for real-time detection in routine clinical examinations while accelerating the process to satisfy increasing demand.
研究纳入18名患者与18名健康受试者，通过发音测试和视频软件量化头部位移，分析其与疾病严重程度的关联。
关联不能独立证明早期诊断；在线2021年、卷期2022年。
Correlation between head tremble and the severity of Parkinson's disease.
题录 P0204 · CV 标注年 2021 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
Introduction Parkinson's (PD) is a common degenerative disease of the central nervous system. It affects more than 6 million individuals worldwide. The typical clinical manifestations include static tremor, slow movement, and unstable posture. However, the correlation between head tremor and the severity of PD remains unclear. Methods In the current study, 18 patients and 18 healthy subjects were recruited to undergo a phonation test. Noldus facereader 7.0 software was used to analyze the range of head trembling between the two groups. Results The data revealed that patients with PD had significant differences in the x-, y-, and z-axis of head movement with respect to the specific pronunciation syllables compared with the normal group. Moreover, the head movement of the patients with PD was positively correlated with the severity of the disease in the single, double, and multiple syllable tests. In the phonetic test, the head displacement of patients with PD was significantly greater than that of healthy individuals, and the displacement range was positively correlated with the severity of the disease. Conclusion These pieces of evidence suggested that the measurement of head displacement assists the early diagnosis and severity of the disease.
系统评价纳入19项研究、5614名参与者，比较第三心音与左室射血分数的心衰诊断表现。
第三心音单用敏感性较低，不能写心音可替代超声或排除心衰。
A systemic review and meta-analysis comparing the ability of diagnostic of the third heart sound and left ventricular ejection fraction in heart failure.
题录 P0194 · CV 标注年 2022 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
Objective This study aimed to compare the sensitivity and specificity of diagnosis between the third heart sound (S3) and left ventricular ejection fraction (LVEF) in heart failure (HF). Methods Relevant studies were searched in PubMed, SinoMed, China National Knowledge Infrastructure, and the Cochrane Trial Register until February 20, 2022. The sensitivity, specificity, likelihood ratio (LR), and diagnostic odds ratio (DOR) were pooled. The symmetric receiver operator characteristic curve (SROC) and Fagan's nomogram were drawn. The source of heterogeneity was explored by meta-regression and subgroup analysis. Results A total of 19 studies, involving 5,614 participants, were included. The combined sensitivity of S3 was 0.23 [95% confidence interval (CI) (0.15-0.33), specificity was 0.94 [95% CI (0.82-0.98)], area under the SROC curve was 0.49, and the DOR was 4.55; while the sensitivity of LVEF was 0.70 [95% CI (0.53-0.83)], specificity was 0.79 [95% CI (0.75-0.82)], area under the SROC curve was 0.79, and the DOR was 8.64. No publication bias was detected in Deeks' funnel plot. The prospective design, partial verification bias, and blind contributed to the heterogeneity in specificity, while adequate description of study participants contributed to the heterogeneity in sensitivity. In Fagan's nomogram, the post-test probability was 48% when the pre-test probability was set as 20%, while in LVEF, the post-test probability was 45% when the pre-test probability was set as 20%. Conclusion The use of S3 alone presented lower sensitivity in diagnosing HF compared with LVEF, whereas it was useful in early pathological assessment.
该综述讨论胰腺癌术前治疗、外科策略及系统治疗。作品库《外科红黑版画系列》中的对应插画与原文 Figure 2 同源。
原图注 Drawn by FFL，贡献声明 LFF drew the images，作者表列 Fangfang Liu；不据此认定公司权属。
Landmarks in pancreatic cancer studies.
题录 P0189 · CV 标注年 2022 · 日期依据 article_pub_date。日期按现有材料的年、月、日精度显示。
F147 对应论文 Figure 2；原图注 Drawn by FFL，贡献声明 LFF drew the images，作者表列 Fangfang Liu；保留原文缩写，图被采用不等于公司所有权或公司致谢。
Pancreatic cancer is a rare but fatal disease. Patients present advanced disease due to the lack of or typical symptoms when the tumor is still localized. A high-quality image processing system has been in practice to detect the pancreatic tumor and determine the possibility of surgery, and preoperative methods, such as ERCP are increasingly used to complement the staging modality. Pancreaticoduodenectomy is one of the complicated surgeries with potential morbidity. The minimally invasive pancreatic resections, both robot-assisted and laparoscopic, have become a part of standard surgical practice worldwide over the last decade. Moreover, advancements in adjuvant chemotherapy have improved the long-term outcomes in current clinical practice. The systemic conservative treatment, including targeted agents, remains the mainstay of treatment for patients with advanced disease. An increasing number of studies are focused on modulating the pancreatic tumor microenvironment to improve the efficacy of the immunotherapeutic strategies. Herein, the role of preoperative therapy, the novel surgical strategy, and individualized systemic treatment in pancreatic cancer is investigated. Also, the randomized controlled studies that have defined the neoadjuvant and surgical management of pancreatic cancer have been summarized.
题录确认研究关注脑电与面部表情、睡眠行为的关联；本轮缺正文，不补写方向、效应和样本量。
题名相关性不能证明公司已有多模态平台。
Correlation analysis between EEG data and facial expressions and sleep behaviors
题录 P0184 · CV 标注年 2023 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
现有材料未包含可读摘要，不据题名补写研究结论。
研究对90名健康成年男性开展36小时睡眠剥夺观察，结合心音测量与功能磁共振分析脑心指标变化。
限特定实验人群，不能推广为居家病情监测；在线日期仍需出版方复核。
Changes in brain function and heart sound in acute sleep deprivation individuals.
题录 P0183 · CV 标注年 2023 · 日期依据 crossref_published-print。日期按现有材料的年、月、日精度显示。
Aims Sleep deprivation (SD) has become a health problem in modern society due to its adverse effects on different aspects. However, the relationship between sleep and cardiovascular system function remains unclear. Here we explored the changes occurring in the brain and the heart sounds after SD. Methods Ninety healthy adult men were recruited and subjected to 36 h of Sleep Deprivation (SD). They participated in a number of tests, including measurements of the heart sound, blood oxygen, and heart rate every 2 h. By using of principal component analysis to reduced the dimensionality of heart sound data. While the ALFF and ReHo indexes were measured via fMRI before and after SD. Correlation and regression analyses were used to reveal the relationship between fMRI and heart sound changes due to SD. Results In this study, there were no abnormal values in the heart rate and blood oxygen during 36 h of SD, whereas the intensity of heart sounds fluctuated significantly increased and decreased. The ALFF was increased in bilateral pericalcarine(Calcarine), left anterior cuneus, (Precuneus_L), right superior temporal gyrus(Temporal_Sup_R), left supplementary motor area (Supp_Motor_Area_L); However, it was reduced in the right medial superior frontal gyrus (Frontal_Sup_Medial_R), right dorsolateral superior frontal gyrus (Frontal_Sup_R) and left medial frontal gyrus (Frontal_Mid_L). The regression analysis uncovered that the intensity of the heart sound in the systole, s1, and s2 phase could be explained by Calcarine_L changes. Conclusion Acute sleep deprivation affects cardiac-brain axis and the specific brain regions. Calcarine_L changes during sleep deprivation are involved in regulating heart contractions.
研究设计音频分析工具，对心动周期及第一、第二心音进行时间标签分割，并以指脉氧仪心率作验证参考。
原文发表2024-01-11，卷/DOI含2023；不表述为完整心脏病诊断系统。
Construction and validation of a method for automated time label segmentation of heart sounds.
题录 P0180 · CV 标注年 2024 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
Heart sound detection technology plays an important role in the prediction of cardiovascular disease, but the most significant heart sounds are fleeting and may be imperceptible. Hence, obtaining heart sound information in an efficient and accurate manner will be helpful for the prediction and diagnosis of heart disease. To obtain heart sound information, we designed an audio data analysis tool to segment the heart sounds from single heart cycle, and validated the heart rate using a finger oxygen meter. The results from our validated technique could be used to realize heart sound segmentation. Our robust algorithmic platform was able to segment the heart sounds, which could then be compared in terms of their difference from the background. A combination of an electronic stethoscope and artificial intelligence technology was used for the digital collection of heart sounds and the intelligent identification of the first (S1) and second (S2) heart sounds. Our approach can provide an objective basis for the auscultation of heart sounds and visual display of heart sounds and murmurs.
摘要描述60名健康男性在36小时睡眠剥夺前后的功能连接、警觉、情绪与困倦指标变化。
在线发表 2024-11-22，卷期为 2025-01；功能连接改变不等于脑区失联。
The impact of sleep deprivation on the functional connectivity of visual-related brain regions.
题录 P0174 · CV 标注年 2024 · 日期依据 europepmc_firstPublicationDate。日期按现有材料的年、月、日精度显示。
Background Sleep deprivation(SD) is known to impair cognitive function and emotional regulation, however, its specific effects on the functional connectivity of visual-related brain regions remain unclear. Objectives This study aimed to investigate the impact of 36-h acute sleep deprivation on functional connectivity in visual neural circuits and its relationship with cognitive and emotional changes. Methods Sixty healthy male participants were assessed before and after 36 h of sleep deprivation using resting-state fMRI, the Psychomotor Vigilance Task (PVT), the Epworth Sleepiness Scale (ESS), and the Profile of Mood States (POMS). Functional connectivity changes were analyzed using paired t-tests and False Discovery Rate (FDR) correction. Key results Sleep deprivation significantly altered functional connectivity between the prefrontal cortex, hippocampus, and visual processing regions. These changes correlated with slower PVT reaction times, increased subjective sleepiness (ESS), and emotional disturbances (POMS), including heightened tension and reduced self-esteem. Conclusions The findings suggest that acute sleep deprivation impairs cognitive performance and emotional regulation by changing functional connectivity in key brain regions. These results may strengthen our understanding of neurobiology of SD and its potential negative effects.
研究分析226段婴儿哭声音频，分割吸气和呼气阶段，提取时长、频率和强度并比较早产与足月背景差异。
226是音频片段而非婴儿人数；不是脑损伤诊断产品。
阅读研究快读 → · 论文 DOI · PubMed 41039324
Construction and validation of an automated time label segmentation method for infant cries.
题录 P0158 · CV 标注年 2025 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
AcknowledgementsAcknowledgments: We thank the undergraduate candidates SQC, WZH, LYF, who performed clinical examinations in community hospitals and provided valuable suggestions for this study. Dr Huang Kun provided valuable software segmentation experience for this study. The valuable support from the medical sound database from Chengdu Medical College (http://ama.cmc.edu.cn) and professional discussion from Chengdu Zhiju Data Science Technology Co., Ltd. (www.zjdatast.cn).
公司贡献限 professional discussion（专业讨论）；医学声音数据库归属成都医学院。
Infant cries serve as critical indicators of an infant's physiological and psychological states, holding essential clinical value in distinguishing between normal and pathological conditions during early development. However, most studies on infant cries failed to segment between inhalation and exhalation during the crying analysis because segmentation remains great challenge. Therefore, we developed an audio data analysis tool capable of accurately segmenting inhalation and exhalation phases in infant cries, followed by extraction of the duration, frequency, and intensity parameters of each segment. Here, 226 sound clips of infants' cries were collected and analyzed. The results revealed the significant differences in sound parameters between premature and term infants. The whole process allows automatic identification and digital collection of infant cries, and it provides an objective method to evaluate the significance behind the cries.
研究采集84名患者的呼吸音，进行时间标签分割与特征提取，比较不同疾病背景下的呼吸周期指标。
公司在致谢中获得professional discussion感谢；不是独家数据或商业交付。
Construction and Validation of an Automatic Segmentation Method for Respiratory Sound Time Labels.
题录 P0157 · CV 标注年 2025 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
AcknowledgmentsWe give special thanks for the valuable support from the medical sound database from Chengdu Medical College (http://ama.cmc.edu.cn) and the professional discussion from Chengdu Zhiju Data Science Technology Co. Ltd. (www.zjdatast.cn).
公司贡献限 professional discussion（专业讨论）；医学声音数据库归属成都医学院。
Background In the field of respiratory system diseases, the utilization of respiratory sounds in auscultation plays a crucial role in the specific disease diagnosis. However, during the process of auscultation, the personal experiences and environmental factors may affect the decision making, leading to diagnostic errors. Therefore, to accurately and effectively obtain and analyze respiratory sounds can be positively contribute to the diagnosis and treatment of respiratory system diseases. Objectives Our aim was to develop an analytical method for the visualization and digitization of respiratory audio data, and to validate its capability to differentiate between various background diseases. Methods This study collected the respiratory sounds of patients admitted to the Department of General Medicine of Shanghai Changhai Hospital from June to December 2023. After strict screening according to the inclusion and exclusion criteria, a total of 84 patients were included. The research process includes using an electronic stethoscope to collect lung sounds from patients in a quiet environment. The patients expose their chests and lie flat. Sound data are collected at six landmark positions on the chest. The collected audio files are imported into an analysis tool for segmentation and feature extraction. Specific analysis methods include distinguishing heart sounds and respiratory sounds, segmenting respiratory sounds, determining the inspiratory and expiratory phases, and using a tool developed by the team for automatic segmentation encoding. Results We standardized the respiratory sounds of 84 patients and segmented multiple respiratory cycles. Following the localization and segmentation of the respiratory cycles based on label information, we calculated the average and standard deviation of the amplitude features for each segment of the respiratory cycle. The results indicated differences among various diseases. Conclusions The robust algorithm platform is capable of segmenting the respiratory sounds into inhale and exhale phases accordingly, then comparing the difference between different background diseases. This method provides objective evidence for the auscultation of respiratory sounds and visual display of breath sounds.
研究观察38名健康大学生在三档逐步增强的噪声条件下完成任务，结合fNIRS与生理表情指标分析。
固定递增顺序可能混入顺序效应；不写通用最佳分贝或噪声疗法。
The impact of different decibels of ambient noise on attention.
题录 P0147 · CV 标注年 2026 · 日期依据 crossref_published-online。日期按现有材料的年、月、日精度显示。
Ambient noise is often perceived as a distractor; however, some individuals may benefit from certain levels of ambient noise to enhance cognitive performance. Despite this, the optimal range of ambient noise for improving attention remains unclear. To disclose this relationship, thirty-eight healthy college students were recruited to perform a 6 ⋅ 6 Schulte grid test under varying ambient noise levels. All participants performed the tasks under three noise conditions presented in a fixed order of increasing intensity (20-40 dB, 40-60 dB, and 60-80 dB). Functional near-infrared spectroscopy (fNIRS) was employed to measure dynamic changes in hemoglobin levels, while facial expressions and physiological signs were also assessed. The findings demonstrated that 40-60 dB group exhibited strongest visual brain functional connectivity. Among the three groups, the 40-60 dB group exhibited the highest values for anger expression, surprise expression, and heart rate (HR) (all p < 0.0001). Additionally, this group showed significantly higher heart rate variability (SDNN) compared to the 60-80 dB group (p < 0.05). The region of interest (ROI) pars triangularis Broca's area left~ pars triangularis Broca's area right revealed a significant difference (P = 0.004). Furthermore, the pairwise post hoc tests revealed the significant differences between the 20-40 dB group and 60-80 dB group (P = 0.007), as well as between the 40-60 dB group and 60-80 dB group (P = 0.017). In conclusion, moderate noise (40-60 dB) appears to induce an optimal level of arousal. In contrast, high-intensity noise (60-80 dB) likely prompts functional reorganization between the bilateral triangular parts of Broca's area to support cognitive control and interference suppression.The moderate intensity of noise may arouse the attention.
研究纳入300名18至22岁大学生，设置三组实验并结合fNIRS、表情及生命体征观察视觉刺激与决策。
探索性研究非营销效果承诺；公司贡献仅professional discussion。
The Effect of Culture Mix or Not Conflict Against the Decision Making-A fNIRS Study.
题录 P0145 · CV 标注年 2026 · 日期依据 epub。日期按现有材料的年、月、日精度显示。
AcknowledgementsWe specially thank the valuable support from the medical sound database from Chengdu Medical College (http://ama.cmc.edu.cn) and professional discussion from Chengdu Zhiju Data Science Technology Co. Ltd. (www.zjdatast.cn).
公司贡献限 professional discussion（专业讨论）；医学声音数据库归属成都医学院。
With increasing globalisation and deepening integration of local cultures, a growing number of product advertisements incorporate diverse, mixed cultural elements, designed to attract consumer attention and enhance purchase interest. However, the underlying mechanisms by which visual stimuli successfully influence consumer purchase behaviour remain poorly understood. In the present study, 300 college students aged 18-22 were recruited and randomly assigned to one of three between-subjects experiments (A, B and C), each comparing a control group (n = 50) with an experimental group (n = 50). The experiment employed a single-exposure paradigm, using functional near-infrared spectroscopy (fNIRS) to monitor changes in participant haemoglobin in brain cortical areas. Facial expressions and vital signs were simultaneously recorded in parallel. Based on these measurements, visual stimuli with mixed cultural elements collectively influence consumer decision-making through their intensity characteristics, potentially involving cognitive conflict processing and may be associated with enhanced emotional arousal and modulated autonomic nervous activity. These results provide exploratory evidence for the neural correlates underlying visual strategies in cross-cultural marketing and offer new methodological support for brand design and consumer cognition studies.
登记条目据徐帆个人学术履历转录；下列名称、版本号与登记号为来源记载，不代表已核实的软件功能。现有材料未包含可核对的登记证书与权利人记录，不据此认定为公司资产；软件著作权登记不等于医疗器械注册，也不代表临床效果已验证。
以上仅为履历来源记载，未作为经登记证书核实的公司资产展示；名称中的评估、监测等措辞不作为已验证临床功能。
