橫幅畫面分三個知識區：A 睡眠剝奪狀態、B 海馬神經元結構變化、C 類淋巴系統在深部磁刺激下的代謝清運。它把“熬夜傷腦”落到機制層面。軟件元數據顯示 2025-02 編輯，僅登記、不作爲創作年。
圖背後的故事
目的：睡眠剝奪會對健康產生多方面影響，但睡眠與心血管系統功能的關係尚不清楚。研究探討睡眠剝奪後大腦與心音的變化。方法：招募 90 名健康成年男性，進行 36 小時睡眠剝奪，每 2 小時測量心音、血氧和心率；通過主成分分析對心音數據降維，並在睡眠剝奪前後用功能磁共振成像測量低頻振幅與局部一致性指標，再用相關及迴歸分析考察腦功能與心音變化之間的聯繫。結果：36 小時內心率和血氧未見異常值，心音強度則出現明顯升降波動；多個腦區的功能指標發生變化。迴歸分析提示，左側距狀皮層的變化可解釋收縮期、第一及第二心音強度的變化。結論：急性睡眠剝奪影響心腦軸及特定腦區，睡眠剝奪期間左側距狀皮層的變化參與心臟收縮調節。
論文摘要（中文譯文 · 原文）
中文譯文 目的 睡眠剝奪（SD）因其多方面的不良影響已成爲現代社會面臨的健康問題，但睡眠與心血管系統功能之間的關係仍不明確。本研究探討睡眠剝奪後大腦與心音的變化。方法 招募90名健康成年男性，接受36小時睡眠剝奪，每2小時測量心音、血氧與心率等；採用主成分分析對心音數據降維，在睡眠剝奪前後以功能磁共振成像（fMRI）測量 ALFF 與 ReHo 指標，並用相關與迴歸分析揭示睡眠剝奪所致 fMRI 與心音變化之間的關係。結果 36小時睡眠剝奪期間，心率與血氧無異常值，而心音強度出現顯著的升降波動。雙側距狀溝（Calcarine）、左側楔前葉（Precuneus_L）、右側顳上回（Temporal_Sup_R）與左側輔助運動區（Supp_Motor_Area_L）的 ALFF 升高；右側額上回內側（Frontal_Sup_Medial_R）、右側背外側額上回（Frontal_Sup_R）與左側內側額回（Frontal_Mid_L）的 ALFF 降低。迴歸分析發現，收縮期、S1 與 S2 時相的心音強度可由左側距狀溝（Calcarine_L）的變化解釋。結論 急性睡眠剝奪影響心腦軸及特定腦區；睡眠剝奪期間左側距狀溝的變化參與心臟收縮的調節。
Aims Sleep deprivation (SD) has become a health problem in modern society due to its adverse effects on different aspects. However, the relationship between sleep and cardiovascular system function remains unclear. Here we explored the changes occurring in the brain and the heart sounds after SD. Methods Ninety healthy adult men were recruited and subjected to 36 h of Sleep Deprivation (SD). They participated in a number of tests, including measurements of the heart sound, blood oxygen, and heart rate every 2 h. By using of principal component analysis to reduced the dimensionality of heart sound data. While the ALFF and ReHo indexes were measured via fMRI before and after SD. Correlation and regression analyses were used to reveal the relationship between fMRI and heart sound changes due to SD. Results In this study, there were no abnormal values in the heart rate and blood oxygen during 36 h of SD, whereas the intensity of heart sounds fluctuated significantly increased and decreased. The ALFF was increased in bilateral pericalcarine(Calcarine), left anterior cuneus, (Precuneus_L), right superior temporal gyrus(Temporal_Sup_R), left supplementary motor area (Supp_Motor_Area_L); However, it was reduced in the right medial superior frontal gyrus (Frontal_Sup_Medial_R), right dorsolateral superior frontal gyrus (Frontal_Sup_R) and left medial frontal gyrus (Frontal_Mid_L). The regression analysis uncovered that the intensity of the heart sound in the systole, s1, and s2 phase could be explained by Calcarine_L changes. Conclusion Acute sleep deprivation affects cardiac-brain axis and the specific brain regions. Calcarine_L changes during sleep deprivation are involved in regulating heart contractions.